DL-Propargylglycine

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1.What is the DL-Propargylglycine ?

White to off-white powder

Propargylglycine (64165-64-6) is an irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. Propargylglycine reduces inflammation in a rodent carrageenan-induced hindpaw edema model3 and ameliorates gentamycin-induced nephrotoxicity1.

2.What is the CAS number for DL-Propargylglycine ?

The CAS number of DL-Propargylglycine is 64165-64-6.

3.What are another words for DL-Propargylglycine ?

Synonyms?for?DL-Propargylglycine 64165-64-6:Propargyl glycine

4.What is DL-Propargylglycine (64165-64-6) used for?

Used in Pharmaceutical Industry:
DL-Propargylglycine is used as an inhibitor for the enzyme cystathione-γ-lyase, which plays a crucial role in hydrogen sulfide biosynthesis. By inhibiting this enzyme, DL-Propargylglycine can help regulate H2S production, which has been linked to various physiological and pathological processes. This application is particularly relevant in the development of treatments for conditions associated with abnormal H2S levels.
Used in Medical Research:
DL-Propargylglycine is used as a research tool to study the role of hydrogen sulfide in various biological processes. Its ability to inhibit H2S production makes it a valuable compound for investigating the effects of H2S on cellular functions, signaling pathways, and disease progression. This application is essential for advancing our understanding of H2S biology and its potential as a therapeutic target.
Used in Inflammation Management:
DL-Propargylglycine is used as an anti-inflammatory agent in rodent models of inflammation, such as carrageenan-induced hindpaw edema. Its ability to reduce inflammation can be beneficial in the development of treatments for inflammatory conditions, including arthritis, autoimmune diseases, and other disorders characterized by excessive inflammation.
Used in Nephrotoxicity Prevention:
DL-Propargylglycine is used to ameliorate gentamycin-induced nephrotoxicity, a common side effect of gentamycin, an antibiotic used to treat various bacterial infections. By reducing the toxic effects of gentamycin on the kidneys, DL-Propargylglycine can help improve patient outcomes and minimize the risk of kidney damage associated with gentamycin use.

InChI:InChI=1/C5H7NO2.ClH/c1-2-3-4(6)5(7)8;/h1,4H,3,6H2,(H,7,8);1H

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5.Buy DL-Propargylglycine with the best price .

Hubei VASTER Biological Chemical Technology Limited is a quality supplier of DL-Propargylglycine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on DL-Propargylglycine 64165-64-6.